Celtics vs. 76ers prediction, odds, line, spread: 2022 NBA picks, opening night best bets from advanced model

One of sport’s classic rivalries will be renewed on 2022 NBA opening night as the defending Eastern Conference champion Boston Celtics host the Philadelphia 76ers. The team’s have met in the playoffs 21 times — which is more than any other matchup — and each is expected to contend for the East’s crown this year. Boston went 51-31 last year under stars Jayson Tatum and Jaylen Brown and split the season series 2-2 with Philly. The Sixers, who are powered by Joel Embiid and James Harden, had the same 51-31 record but lost in the second round of the playoffs. Robert Williams III (knee) will miss the beginning of the season for Boston. 

Tip-off is set for Tuesday at 7:30 p.m. ET from TD Garden in Boston. Caesars Sportsbook has Boston as the 3-point home favorite in the latest 76ers vs. Celtics odds, with the over/under for total points at 216.5. Before making any Celtics vs. 76ers picks, you’ll want to see the NBA predictions and betting advice from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four seasons. The model went a stunning 88-60 on all top-rated NBA picks last season, returning more than $2,100. Anyone following it has seen huge returns.

Now, the model has set its sights on Celtics vs. Sixers. You can head to SportsLine to see its picks. Here are several NBA betting lines and trends for Sixers vs. Celtics:

  • Celtics vs. 76ers spread: Celtics -3
  • Celtics vs. 76ers over/under: 216.5 points
  • Celtics vs. 76ers money line: Celtics -165, 76ers +140
  • PHI: The 76ers were 23-23-1 against the spread in 2021-22 road games
  • BOS: The Celtics were 23-28-2 against the spread in 2021-22 home games
  • Celtics vs. 76ers picks: See picks at SportsLine

Featured Game | Boston Celtics vs. Philadelphia 76ers

Why the 76ers can cover

Tatum and Brown are as talented as any duo in the league, and with both still in their mid-20s, there’s room for even more growth. Tatum has increased his scoring average every season, but he brings more than just points to the table as he’s also increased both his rebounds and assists every year as well. Meanwhile, Brown ranked 13th in the NBA with 23.6 PPG, and while that total ranked second on his own team, it would have led 19 other NBA teams.

Even with the Tatum and Brown duo, Boston’s greatest strength is its defense which finished second in the league in defensive efficiency last season. The Celtics led the league in opposing field goal percentage, and they could put the clamps down on a Sixers team that ranked among the bottom half of the league in FG% last season. Philly also ranked among the bottom 10 in 3-pointers made, so it will be tough for it to generate points beyond the arc against Boston’s defense which led the league in opposing 3P%.

Why the Celtics can cover

Boston’s defense is elite by any description. The Celtics led the NBA in defensive efficiency last season, yielding only 106.2 points per 100 possessions. Boston also has the best defense when it comes to contesting shots, leading the NBA in 3-point percentage allowed, 2-point percentage allowed and field goal percentage allowed. With opponents averaging only 21.6 assists per game against Boston, nothing comes easy, and the Celtics also finished No. 2 in the league with 5.6 blocks per game last year. On the offensive end, Boston is also potent and varied, with multiple shot creators. 

Tatum leads the way as a two-time All-NBA selection after a 2021-22 season in which he averaged 26.9 points and 8.0 rebounds per game. Alongside Tatum is another All-Star wing in Brown, who averaged 24.1 points per game in the last two seasons combined, and the Celtics ranked in the top six of the NBA in free throw accuracy (81.6%) and 2-point accuracy (54.7%) in 2021-22.

How to make 76ers vs. Celtics picks

The model is leaning Under on the total, projecting 212 combined points. It also says one side of the spread hits well over 50% of the time. You can only see the pick at SportsLine.

So who wins Celtics vs. Sixers? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.

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